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Van Wyk Grumback Syndrome: A Rare Cause of Precocity in a Common Condition.

Author

Francesca Isabel C. Bunyi,
Cecilia Joyce M. Bascara

Related Institution

Department of Obstetrics and Gynecology - San Juan de Dios Educational Foundation Inc. Hospital

Publication Information

Publication Type
Journal
Publication Sub Type
Case report
Title
Philippine Journal of Reproductive Endocrinology and Infertility
Frequency
Semi-Annual
Publication Date
July-December 2020
Volume
17
Issue
2
Page(s)
31-34

Abstract

A nine-year old myxedematous girl with short stature, isosexual pseudoprecocious puberty and bilateral multicystic ovaries underwent pelvic laparotomy due to an acute abdomen because of adnexal torsion. She also delayed bone, age, severe hypothyroidism, hyperprolactinemia, hyperestrogenism and pituitary adenoma. All of these findings led to the diagnosis of Van Wyk Grumback Syndrome, which is a rare condition characterized by long standing untreated hypothyoidism, pseudoprecocious puberty and nulticystic ovaries. Adminsitration of levothyroxine efected gradual regression and reversal of symptoms. This case highlight the significance of recognizing the clinical features of this syndrome in order to medically treat the child and thus, prevent its undesirable effects in the physial andmental growth an dpossible surgical cimplications that ay affect her future reproductive capacity.

References

1. Van Wyk, JJ . "Syndrome of Precocious menstruation and galactorroea in juvenile hypothyroidism" The Journal of Pediatrics 57(3): 416-35, 1960. Retrieved from: https://doi.org/10.1016/S0022-3476(60)80250-8
2. Waghmare, M , Shah, H , Kumbhar, V , Jayaswal, S . "Van Wyk Grumback Syndrome" International journal research in medical sciences 4(8): 3616-8, 2017. Retrieved from: http://doi:http://dx.doi.org/10.18203/2320-6012.ijrms20162339
3. Bulugahapitiya, DT . "Precocious sexual development in an untreated cretin" Postgrad Med J 48(559): 317-20, 1972
4. Wormsbecker, A , Clarson, C . "Acquired Primary hypothyroidism: vaginal bleeding in a quiet child" Can Med Assoc J 182(6): 588-90, 2010. Retrieved from: http://doi:10.1503/cmaj.090883.
5. Kasem, S . "Precocious Puberty with primary hypothyroidism due to autoimmune thyroiditis" Journal of Bangladesh College of Physicians and Surgeons 34(1): 45-7, 2016. Retrieved from: http://doi:https://doi.org/10.3329/jbcps.v34i1.29167
6. Kendle, F . "Case of precocious puberty in a female cretin" British Medical Journal (1): 246, 1905. Retrieved from: http://doi:https://doi.org/10.1136/bmj.1.2301.246
7. Rastogi, A , Bhadada, SK , Bhansali, A . "An unusual presentation of a usual disorder: Van Wyk-Grumback symdrome" Indian J Endocinol Metab 15(Suppl 2): S141-S3, 2011. Retrieved from: http://doi:10.4103/2230-8210.83356
8. Massart, F , Giuseppe, G . "Hyperprolactinaemia in children - a common diagnosis dilemma" European Journal of Endocrinology (2): 81-3, 2006. Retrieved from: http://doi:10.17925/EE.2006.00.02.81
9. Dharmshaktu, P , Kutiyal, A , Dhanwal, D . "Vanishing large ovarian cyst with hyroxine therapy" Endorinol Dia Metab Case Rep 130050, 2013. Retrieved from: http://doi:10.1530/EDM-13-0050.

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Society of Reproductive Medicine Quezon City Abstract

 
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