i
Report an error   
Advanced Search


Preoperative Gonadotropin Releasing Hormone Agonist Treatment for Giant Endometrial Polyp: A Case Report and Review of Literature.

Author

Richard  G. Malicdan,
Sheryll  Beltran-Carullo

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Reproductive Endocrinology and Infertility
Frequency
Semi-Annual
Publication Date
July-December 2021
Volume
18
Issue
2
Page(s)
45-52

Abstract




Endometrial polyps are localized outgrowths of glands and stroma within the endometrium primarily caused by hyperestrogenism. They are common causes of abnormal uterine bleeding and infertility by altering the endometrial surface. Polyps may be small, large (measuring more than one centimeter), or giant (more than 4 centimeters in size). Large and giant polyps are very rare and prone to oncologic malformation, thus biopsy is recommended. Endometrial resection with biopsy is the gold standard of treatment, but could be difficult since giant endometrial polyps occupy the entire endometrial cavity resulting to morbidity and failure on hysteroscopy. Limited case reports and studies have used gonadotropin releasing hormone (GnRH) agonist as preoperative therapy to decrease polyp size prior to hysteroscopic resection. The aim of this case report is to discuss a rare case of giant endometrial polyp treated with neoadjuvant GnRH agonist prior to hysteroscopic resection, and to present the recent literature regarding giant endometrial polyps.




References

1. Lobo RA, Gershenson , FA . "Com- prehensive Gynecology, 7th ed." hiladelphia: Elsevier, 2017 , 391,
2. Nijkang N, Anderson , F . "En- dometrial polyps: Pathogenesis, sequelae and treatment" SAGE Open Medicine 2019 7, 2050312119,
3. Yang J, Chen C, Chen, M . "Factors in- fluencing the recurrence potential of benign endometrial polyps after hysteroscopic polypectomy" PLOS ONE 2015 10(12): e0144857,
4. Anastasiadis PG, Kou, VA . "Endometrial polyps: prev- alence, detection, and malignant potential in women with abnormal uterine bleeding" Europ J Gynecol Oncol 2000 21, 180-3,
5. Nijkang N, Anderson , F . "En- dometrial polyps: Pathogenesis, sequelae and treatment" SAGE Open Medicine 2019 7, 2050312119,
6. Goldstein S, Monteag, I . "Evaluation of endometrial polyps" American Journal of Obstetrics and Gynecology 186(4): 669-74, 2002
7. Kanthi, J . "Clinical study of endometrial polyp and role of diagnostic hysteroscopy and blind avulsion of polyp" J Clin Diag Res 2016 ,
8. Peterson, W , Novak, E . "Endometrial Polyps" Obstet Gyne- colog Surv 1957 12(2): 264-9,
9. Tyagi S, Manchanda R, M . "Giant endometrial polyp protruding from the external cervical os-a case report" Int J Cur Adv Res 2017 6(5): 3989-92,
10. Çil A, Bozkurt M, Ka, B . "Giant endometrial polyp protruding from the external cervical os in a post- menopausal woman: magnetic resonance imaging and hysteroscopic findings" Proceedings in Obstetrics and Gynecology 2013 3(3): 1-9,
11. Wang, J , Zhao, J , Lin, J . "Opportunities and risk factors for premalignant and malignant transformation of endome- trial polyps: Management strategies" J Minimally Invasive Gynecol 2010 17(1): 53-8,
12. Labrie F, Bélanger A, L, et.al . "Gonadotropin-releasing hormone agonists in the treatment of prostate cancer" Endocr Rev 2005 26(3): 361-79,
13. Steingold KA, Cedars, DR . "Treatment of endometriosis with a long-act- ing gonadotropin-releasing hormone agonist" Obstet Gynecol 1987 69, 403,
14. Hodgson, Ruth, et.al . "GnRH agonists for uterine fi- broids" Cochrane Database of Systematic Reviews 2017 , . Retrieved from: http://doi:10.1002/14651858.cd012846.
15. Cupino-ArcinueD,Tan-, MRP . "NoveluseofGnRH agonist as neoadjuvant treatment for giant endometrial polyps" Philip J Rep Endocrinol Infer 2018 2,
16. Lin, Yu-Hung, et.al . "An adenomyomatous polyp present- ing as a large hypervascular tumor and its response to a gonadotropin-releasing hormone agonist" Taiwanese J Obstet Gynecol 2013 52(1): 129-30, . Retrieved from: http://doi:10.1016/j. tjog.2013.01.016.
17. Vercellini P, Perino, P . "Treatment with a gonadotrophin releasing hormone agonist before endometrial resection: a multi- centre, randomised controlled trial" BJOG 1996 103(6): 562-8,
18. Kumar, P , Sharma, A . "Gonadotropin-releasing hormone analogs: Understanding advantages and limitations" J Hum Reprod Sci 2014 7(3): 170,

 
Loading…
©2022 HERDIN PLUS. All rights reserved.